When sitting at a desk always arrange your posture to maintain the correct spinal curves; especially consider the low back (lumbar) and neck (cervical) spines.
The seat should slope downwards slightly at the front so that the knees are lower than the hips.
The height if the chair is set to keep the wrists in a neutral, resting position.
The back of the chair should support the forward curve of the lumbar spine and extend upwards to give some stability to the shoulder-blades.
The top of the computer screen should be nearly at eyeball height.
Remember to walk around for 10 minutes every hour!